Report

Author: Godfrey-Faussett, Peter
Title: Policy Statement on Preventive Therapy Against Tuberculosis in People Living With HIV: Report of a Meeting Held in Geneva, 18-20 February 1998
Editor: UNAIDS; World Health Organization
Description of Work: WHO/TB/98.255 UNAIDS/98.34
Imprint: UNAIDS, WHO, 1998, 20 pp
Abstract: "Preventive therapy (PT) against tuberculosis is the use of one or more anti-tuberculosis drugs given to individuals with latent infection with Mycobacterium tuberculosis in order to prevent the progression to active disease. HIV is the most powerful known risk factor for progression from latent infection with M. tuberculosis to active disease, and this is the major cause of the large increase over the last decade in the incidence of tuberculosis in populations with a high prevalence of HIV infection. Several large randomised controlled trials have now demonstrated that PT is effective in preventing TB in individuals dually infected with HIV and M.tuberculosis. However, studies of the feasibility of PT demonstrate that the process required to target appropriate individuals, to exclude active tuberculosis, to deliver PT and to achieve adherence is complex and inefficient. In February 1998, WHO and UNAIDS convened a meeting to review the data available and to make recommendations to governments that would serve to update the recommendations published by WHO and IUATLD in 1993. This document presents the recommendations arising from the meeting."

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